COVID-19 hits the global supply chains in a non-paradigm manner unfolding new and systemic complexity. Therefore, the unexpected and frequent disruptions forced the concern of preventing or creating supply chain resilience capabilities. This paper aims to provide theoretical and practical reflections on resilience in supply chains of essential goods during pandemics using a systems approach. Documental research was performed in order to characterize business practices in consulting reports and interviews with managers published in business communication media. Thus, a careful content analysis was carried out, including the coding and categorization of the leading practices indicated by these vehicles. We suggest categories of resilience factors as new concepts to face the new normal in the supply chains. These categories are Technology and People, Sourcing, Customer, Ecosystem, and Financial Assets. The systems approach consists of more qualified supply chain management stimulating several inputs and synchronized actions to sense and respond to the external environment dynamics.